تفاعل #214459

معادلة التفاعل

4-amino-2-chloro-6,7-dimethoxyquinazoline

3-(4-piperidinyl)-3-azaspiro-[5,5]-undecan-2,4-dione

sodium carbonate

→

3-[2-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-piperidinyl]-3-azaspiro[5,5]undecan-2,4-dione monohydrochloride

المذيبات

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   ترشيحIt is filtered
2. 2
   أخرىthe filtrate evaporated
3. 3
   workup.DISSOLUTIONthe residue dissolved in methylene chloride
4. 4
   غسيلthe solution washed with aqueous sodium carbonate
5. 5
   أخرىdried
6. 6
   ترشيحfiltered
7. 7
   أخرىevaporated
8. 8
   أخرىThe residue is triturated with 50 ml of isopropanol

الإجراء التجريبي

The mixture of 2.39 g of 4-amino-2-chloro-6,7-dimethoxyquinazoline, 2.64 g of 3-(4-piperidinyl)-3-azaspiro-[5,5]-undecan-2,4-dione, 2.1 g anhydrous sodium carbonate and 25 ml of dimethylformamide is stirred under nitrogen at 150° for 10 hours. It is filtered, the filtrate evaporated, the residue dissolved in methylene chloride, the solution washed with aqueous sodium carbonate, dried, filtered and evaporated. The residue is triturated with 50 ml of isopropanol, the remainder taken up in isopropanol and the mixture acidified with hydrogen chloride, to yield the 3-[2-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-piperidinyl]-3-azaspiro[5,5]undecan-2,4-dione monohydrochloride melting at 290° (dec.).

المصدر