تفاعل #214454

معادلة التفاعل

glutaric anhydride

4-aminopyridine

→

1-(4-pyridyl)-piperidine-2,6-dione

المذيبات

xylene

ظروف التفاعل

المعالجة

1. 1
   أخرىThe starting material is prepared
2. 2
   درجة الحرارةis refluxed
3. 3
   ترشيحthe solids are filtered off
4. 4
   استخلاصextracted twice with 200 ml chloroform
5. 5
   درجة الحرارةat reflux
6. 6
   أخرىThe combined extracts are evaporated
7. 7
   أخرىthe residue recrystallized twice from ethyl acetate

الإجراء التجريبي

The starting material is prepared as follows: The mixture of 34.2 g of glutaric anhydride, 28.2 g of 4-aminopyridine and 650 ml of xylene is refluxed with stirring for 6 hours. It is allowed to cool to room temperature, the solids are filtered off and extracted twice with 200 ml chloroform at reflux. The combined extracts are evaporated and the residue recrystallized twice from ethyl acetate to yield the 1-(4-pyridyl)-piperidine-2,6-dione melting at 153°-155°.

المصدر