تفاعل #214313

معادلة التفاعل

2-Bromo-1,1-dimethoxyethane

toluene sulfonic acid

potassium carbonate

→

2-bromomethyl-4,5-dimethyl-1,3-dioxolane

ظروف التفاعل

المعالجة

1. 1
   أخرىfitted with a mechanical stirrer
2. 2
   درجة الحرارةthermometer, and reflux condenser
3. 3
   درجة الحرارةThe reaction mixture was heated
4. 4
   درجة الحرارةto reflux for a period of about 2 hours
5. 5
   ترشيحfiltered
6. 6
   workup.DISTILLATIONThe filtrate was distilled

الإجراء التجريبي

2-Bromo-1,1-dimethoxyethane (188 grams) 2,3-butanediol (100 grams) and toluene sulfonic acid (0.1 grams) were charged into a glass reaction vessel fitted with a mechanical stirrer, thermometer, and reflux condenser. The reaction mixture was heated to reflux for a period of about 2 hours. It was then cooled to room temperature, neutralized with potassium carbonate, and filtered. The filtrate was distilled, the desired product 2-bromomethyl-4,5-dimethyl-1,3-dioxolane being obtained as a fraction boiling at 82° C.-85° C. at a pressure of about 12 mm Hg.

المصدر