تفاعل #214145

معادلة التفاعل

1,4-dihydroxy-N-n-hexadecyl-2-naphthamide

methylsulfonylethanol

p-toluenesulfonic acid

toluene

→

( 2 )

1-Hydroxy-4-(β-methylsulfonylethoxy)-N-n-hexadecyl-2-naphthamide

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe mixture was refluxed
2. 2
   درجة الحرارةwith heating for 5 hours
3. 3
   أخرىwas removed
4. 4
   أخرىToluene was removed under reduced pressure
5. 5
   workup.ADDITION100 ml of methanol was added to the mixture
6. 6
   ترشيحThe crystals thus deposited were collected by filtration

الإجراء التجريبي

10 g (0.023 mol) of 1,4-dihydroxy-N-n-hexadecyl-2-naphthamide, 5.7 g (0.046 mol) of methylsulfonylethanol and 4.4 g (0.023 mol) of p-toluenesulfonic acid were added to 50 ml of dehydrated toluene. The mixture was refluxed with heating for 5 hours and the water produced was removed. Toluene was removed under reduced pressure. 100 ml of methanol was added to the mixture. The crystals thus deposited were collected by filtration to obtain 10.8 g (88%) of Coupler (2). Melting Point: 107° to 109° C. (recrystallized from methanol).

المصدر