تفاعل #2139969

معادلة التفاعل

alcohol

2-chloro-4-t-butylbenzyl alcohol

→

2-chloro-4-t-butylbenzaldehyde

المردود 79.0%

المذيبات

chloroform

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter leaving
2. 2
   درجة الحرارةto cool
3. 3
   ترشيحmanganese dioxide was filtered out
4. 4
   تركيزthe filtrate was concentrated under reduced pressure
5. 5
   أخرىAfter the purification by the silica gel column chromatography

الإجراء التجريبي

The alcohol compound (195 mg, 0.981 mmol) obtained in Step 1-3 was dissolved in chloroform (5 ml). Activated manganese dioxide (1.27 g) was added to the obtained solution, and they were violently stirred at 50° C. for 2 hours. After leaving to cool, manganese dioxide was filtered out, and the filtrate was concentrated under reduced pressure. After the purification by the silica gel column chromatography, 2-chloro-4-t-butylbenzaldehyde (yield: 152 mg, 79%) was obtained.

المصدر