تفاعل #2139965

معادلة التفاعل

2,4-Dihydroxybenzaldehyde

hexyl bromide

lithium carbonate

→

4-hexyloxy-2-hydroxybenzaldehyde

المردود 37.0%

المذيبات

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   استخلاصAfter the neutralization with hydrochloric acid followed by the extraction with ethyl acetate
2. 2
   أخرىthe product was purified by the silica gel column chromatography

الإجراء التجريبي

2,4-Dihydroxybenzaldehyde (3.00 g, 21.7 mmol) and hexyl bromide (7.62 ml, 54.3 mmol) were stirred in the presence of lithium carbonate (4.00 g, 54.3 mmol) in dimethylformamide (5 ml) at 55° C. overnight. After the neutralization with hydrochloric acid followed by the extraction with ethyl acetate, the product was purified by the silica gel column chromatography to obtain 4-hexyloxy-2-hydroxybenzaldehyde (yield: 1.77 g, 37%) in the form of a colorless oil.

المصدر