تفاعل #2139964

معادلة التفاعل

methyl iodide

Potassium carbonate

butyl iodide

2,4-dihydroxybenzaldehyde

→

4-butoxy-2-methoxybenzaldehyde

المردود 31.1%

المذيبات

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGwere stirred at room temperature for 12 hours
2. 2
   استخلاصAfter the extraction with ethyl acetate

الإجراء التجريبي

Potassium carbonate (1.50 g, 10.9 mmol) and butyl iodide (666 mg, 3.6 mmol) were added to a solution of 2,4-dihydroxybenzaldehyde (500 mg, 3.6 mmol) in dimethylformamide (5 ml), and they were stirred at room temperature for 2 hours. Then methyl iodide (2.57 ml) was added to the reaction mixture, and they were stirred at room temperature for 12 hours. After the extraction with ethyl acetate followed by the silica gel chromatography, 4-butoxy-2-methoxybenzaldehyde (yield: 233 mg, 31%) was obtained in the form of a colorless oil.

المصدر