تفاعل #2139963

معادلة التفاعل

pyridine

4-formylphenylboronic acid

pyrazole

→

1-(4-formylphenyl)pyrazole

المردود 66.9%

المذيبات

1,4-dioxane

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe reaction mixture was filtered through Celite
2. 2
   تركيزthe obtained filtrate was concentrated
3. 3
   أخرىpurified by the silica gel TLC chromatography

الإجراء التجريبي

Copper acetate (91 mg, 0.5 mmol), pyridine (53 mg, 0.67 mmol) and active Molecular Sieve 4A (250 mg) were added to a solution of 4-formylphenylboronic acid (100 mg, 0.67 mmol) and pyrazole (16 mg, 0.33 mmol) in 1,4-dioxane (4 ml), and they were stirred at room temperature for 72 hours. The reaction mixture was filtered through Celite, and the obtained filtrate was concentrated and then purified by the silica gel TLC chromatography to obtain 1-(4-formylphenyl)pyrazole (yield: 38 mg, 66%) in the form of a white powder.

المصدر