تفاعل #2139961

معادلة التفاعل

diisobutylaluminum hydride

4-(4-nitrophenyl)benzonitrile

methanol

water

→

4-(4-nitrophenyl)benzaldehyde

المذيبات

toluene

toluene

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGwere stirred
2. 2
   تجفيفThe reaction mixture was dried over sodium sulfate
3. 3
   أخرىAfter the purification by the silica gel column chromatography (ethyl acetate/hexane)

الإجراء التجريبي

1 M solution (1.2 ml, 1.22 mmol) of diisobutylaluminum hydride in toluene was slowly added to a solution (10 ml) of 4-(4-nitrophenyl)benzonitrile (224 mg, 1 mmol) in toluene at room temperature, and they were stirred for 1 hour. After cooling to 0° C., methanol (0.4 ml) and water (0.4 ml) were slowly added to the obtained mixture, and they were stirred. The reaction mixture was dried over sodium sulfate. After the purification by the silica gel column chromatography (ethyl acetate/hexane), 4-(4-nitrophenyl)benzaldehyde was obtained in the form of a yellow solid (yield: 127 mg, 56%).

المصدر