تفاعل #2139957

ord-9847e97939a745d88de102c31d00ce24

معادلة التفاعل

COc1cc2c(c(OC)c1OC)-c1ccc(OC)c(=O)cc1[C@@H](NC(C)=O)CC2
Colchicine
C[S-].[Na+]
sodium methanethiolate
→
COc1cc2c(c(OC)c1OC)-c1ccc(SC)c(=O)cc1[C@@H](NC(C)=O)CC2
desired compound
COc1cc2c(c(OC)c1OC)-c1ccc(SC)c(=O)cc1[C@@H](NC(C)=O)CC2
Thiocolchicine

المتفاعلات

COc1cc2c(c(OC)c1OC)-c1ccc(OC)c(=O)cc1[C@@H](NC(C)=O)CC2
Colchicine
C[S-].[Na+]
sodium methanethiolate

الكواشف

لا شيء

المذيبات

O
water

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    استخلاصextracted 3× with ETOH
  2. 2
    أخرىChloroform (1:1), then evaporated

الإجراء التجريبي

Colchicine (1.25 mmole) was dissolved in 10.0 mL of water to which was added sodium methanethiolate (7.13 mmol). The yellow solution was stirred for 24 hours, then extracted 3× with ETOH:Chloroform (1:1), then evaporated to yield the desired compound as yellow crystals.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US07326685B2uspto-grants-2008_02