تفاعل #2139951

معادلة التفاعل

3-butoxy-4,7-difluoro-8-(4-pentylcyclohexyl)-benzo[c]chromen-6-one

Lawesson's reagent

→

3-butoxy-4,7-difluoro-8-(4-pentylcyclohexyl)benzo[c]chromene-6-thione

المردود 65.3%

المذيبات

chlorobenzene

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe solution was subsequently filtered through silica gel
2. 2
   أخرىevaporated
3. 3
   أخرىthe crude product was purified by crystallisation from MTB ether

الإجراء التجريبي

11.7 g (25.6 mmol) of 3-butoxy-4,7-difluoro-8-(4-pentylcyclohexyl)-benzo[c]chromen-6-one and 11.4 g (28.2 mmol) of Lawesson's reagent were refluxed for 16 hours in 130 ml of chlorobenzene. The solution was subsequently filtered through silica gel and evaporated, and the crude product was purified by crystallisation from MTB ether, giving 7.9 g (65%) of 3-butoxy-4,7-difluoro-8-(4-pentylcyclohexyl)benzo[c]chromene-6-thione as yellow crystals.

المصدر