تفاعل #213918

معادلة التفاعل

sodium bicarbonate

2-(8-hydroxy-7-oxo-octyl)cyclopent-2-en-1-one

ethylene glycol

P-toluenesulfonic acid

→

title compound

2-(8-hydroxy-7-oxo-octyl)cyclopent-2-en-1-one-7-ethylene ketal

المذيبات

toluene

ظروف التفاعل

المعالجة

1. 1
   استخلاصThe mixture is extracted with benzene
2. 2
   غسيلThe organic solution is washed three times with water
3. 3
   تجفيفdried over magnesium sulfate
4. 4
   أخرىThe solvent is removed
5. 5
   أخرىto give 6.0 g

الإجراء التجريبي

A solution of 5.5 g. of 2-(8-hydroxy-7-oxo-octyl)cyclopent-2-en-1-one (Example 88), 25 ml. of ethylene glycol, and 0.1 g. of P-toluenesulfonic acid in 200 ml. of toluene is reflucted for 40 minutes using a Dean-Stark trap. The solution is poured into saturated sodium bicarbonate. The mixture is extracted with benzene. The organic solution is washed three times with water and dried over magnesium sulfate. The solvent is removed to give 6.0 g. of the title compound.

المصدر