تفاعل #2123278

ord-ac1c70f968ad4db789ffcea3a44e01b8

معادلة التفاعل

[Li+].[O-][Cl+3]([O-])([O-])[O-]
lithium perchlorate
O=C(OCc1ccccc1)N1CCC2(CC1)CO2
benzyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate
Nc1cccc(F)c1
3-fluoroaniline
O=C(OCc1ccccc1)N1CCC(O)(CNc2cccc(F)c2)CC1
benzyl 4-{[(3-fluorophenyl)amino]methyl}-4-hydroxypiperidine-1-carboxylate

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

The object product (2.53 g, 94%) was obtained in the same manner as in Example 24(1) and using benzyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate (1.98 g), 3-fluoroaniline (889 mg) and lithium perchlorate (960 mg).

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US08575167B2uspto-grants-2013_11