تفاعل #2112

معادلة التفاعل

7-benzyl-3-methylxanthine

diethyl 4-chlorobutanephosphonate

potassium carbonate

→

Diethyl [4-(7-benzyl-3-methylxanthin-1-yl)butyl]phosphonate

المذيبات

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   ترشيحfiltered
2. 2
   تركيزthe filtrate was concentrated under reduced pressure
3. 3
   ترشيحfiltered again
4. 4
   أخرىcrystallized from diisopropyl ether

الإجراء التجريبي

20.4 g (0.08 mol) of 7-benzyl-3-methylxanthine were suspended in 200 ml of dimethylformamide (DMF), treated with 22 g (0.96 mol) of diethyl 4-chlorobutanephosphonate and 13.8 g (0.1 mol) of activated potassium carbonate and heated at 70° C. for 4 hours and filtered, the filtrate was concentrated under reduced pressure and the oily residue which remained was taken up in ethyl acetate, filtered again and crystallized from diisopropyl ether.

المصدر