تفاعل #2111

معادلة التفاعل

diethyl 1,1-dimethyl-5-(tetrahydropyran-2-yloxy)-5-pentylphosphonate

pyridinium toluene-4-sulfonate

ethanol

→

Diethyl 5-hydroxy-1,1-dimethylpentylphosphonate

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was evaporated
2. 2
   ترشيحthe solution was filtered through a silica gel column
3. 3
   أخرىafter evaporating the solvent
4. 4
   workup.DISTILLATIONthe residue was distilled in a bulb tube

الإجراء التجريبي

19.9 g (0.052 mol) of diethyl 1,1-dimethyl-5-(tetrahydropyran-2-yloxy)-5-pentylphosphonate were stirred at 55° C. for 8 hours with 1.5 g (0.006 mol) of pyridinium toluene-4-sulfonate in 200 ml of aqueous ethanol. The solvent was evaporated, the residue was taken up in ethyl acetate, the solution was filtered through a silica gel column and, after evaporating the solvent, the residue was distilled in a bulb tube.

المصدر