تفاعل #2109

معادلة التفاعل

diethyl 5-hydroxypentylphosphonate

3,4-dihydropyran

pyridinium toluene-4-sulfonate

→

Diethyl 5-(tetrahydropyran-2-yloxy)pentylphosphonate

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةunder reflux for 16 hours
2. 2
   غسيلThe solution was washed with water and saturated sodium hydrogen carbonate solution
3. 3
   تجفيفdried over sodium sulfate
4. 4
   workup.DISTILLATIONdistilled in a bulb tube

الإجراء التجريبي

A solution of 66.9 g (0.298 mol) of diethyl 5-hydroxypentylphosphonate, 32.6 g (0.38 mol) of 3,4-dihydropyran and 1 g (0.004 mol) of pyridinium toluene-4-sulfonate in 800 ml of dichloromethane was heated under reflux for 16 hours. The solution was washed with water and saturated sodium hydrogen carbonate solution, dried over sodium sulfate and distilled in a bulb tube.

المصدر