تفاعل #2090

معادلة التفاعل

1-ethyl-3-methylxanthine

diethyl chlorobutanephosphonate

potassium carbonate

→

Diethyl [4-(1-ethyl-3-methylxanthin-7-yl)butyl]phosphonate

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe solution was filtered
2. 2
   أخرىthe solvent was evaporated
3. 3
   أخرىthe residue which remained was chromatographed (eluent: ethyl acetate/methanol 10: 1)
4. 4
   أخرىcrystallized from ethyl acetate/diisopropyl ether

الإجراء التجريبي

9.7 g (0.05 mol) of 1-ethyl-3-methylxanthine were stirred at 70° C. for 6 hours with 12.7 g (0.06 mol) of diethyl chlorobutanephosphonate and 8.3 g of potassium carbonate. The solution was filtered, the solvent was evaporated, and the residue which remained was chromatographed (eluent: ethyl acetate/methanol 10: 1) and crystallized from ethyl acetate/diisopropyl ether.

المصدر