تفاعل #2087

معادلة التفاعل

diethyl [4-(1-benzyl-3-methylxanthin-7-yl)-butyl]phosphonate

ammonia

→

Diethyl [4-(3-methylxanthin-7-yl)butyl]phosphonate

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe catalyst was filtered off
2. 2
   أخرىthe solvent was evaporated under reduced pressure
3. 3
   أخرىthe residue which remained was crystallized from diisopropyl ether

الإجراء التجريبي

13 g (0.03 mol) of diethyl [4-(1-benzyl-3-methylxanthin-7-yl)-butyl]phosphonate were suspended in 150 ml of ethanol with 2 g of palladium on activated carbon (10%) and, after addition of 3 ml of concentrated ammonia solution, hydrogenated with shaking at 1.5 bar in the course of 48 hours. The catalyst was filtered off, the solvent was evaporated under reduced pressure and the residue which remained was crystallized from diisopropyl ether.

المصدر