تفاعل #2086

معادلة التفاعل

1-benzyl-3-methylxanthine hydrochloride

diethyl 4-chlorobutanephosphonate

potassium carbonate

→

Diethyl [4-(1-benzyl-3-methylxanthin-7-yl)butyl]phosphonate

المذيبات

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe solution was filtered hot
2. 2
   أخرىthe dimethylformamide was evaporated under reduced pressure
3. 3
   غسيلwashed several times with water
4. 4
   أخرىAfter evaporating the solvent, it
5. 5
   أخرىwithout purification

الإجراء التجريبي

20 g (0.078 mol) of 1-benzyl-3-methylxanthine hydrochloride, 21.4 g (0.094 mol) of diethyl 4-chlorobutanephosphonate and 26 g (0.2 mol) of potassium carbonate were suspended in 400 ml of dimethylformamide and stirred at 70° C. for 6 hours. The solution was filtered hot and the dimethylformamide was evaporated under reduced pressure. The oily residue which remained was taken up in dichloromethane and washed several times with water. After evaporating the solvent, it was possible to reuse the pale yellow, oily residue without purification.

المصدر