تفاعل #2083082

معادلة التفاعل

4-Chlorobenzoylisothiocyanate

urea

→

white solid

المردود 51.2%

N-(4-chlorobenzoyl)-N'-carbamoyl thiourea

المردود 51.2%

المذيبات

THF

THF

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe precipitate is filtered
2. 2
   غسيلwashed with ether
3. 3
   أخرىdried

الإجراء التجريبي

A solution of 4-Chlorobenzoylisothiocyanate (152.4 g) in THF (500 ml) is added dropwise to a stirred suspension of urea (46.3 g) in THF (750 ml). The reaction mixture is stirred over the weekend. The precipitate is filtered, washed with ether and dried leaving 101.7 g of a white solid, m.p. 155°-158° C. The filtrate is evaporated, filtered, the solid washed with ether and recrystallized from dioxane to give 7.8 g of additional white solid.

المصدر