تفاعل #2080299

معادلة التفاعل

CH3CN

6

Dietyl(2-amino-1,1-dimethyl-ethyl)phosphonate

TMSBr

→

2-Amino-1,1-dimethyl-ethyl phosphonic acid

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   تركيزconcentrated
2. 2
   تركيزconcentrated to dryness
3. 3
   أخرىto give crude 7 which
4. 4
   أخرىwas used for next reaction without further purification

الإجراء التجريبي

A solution of CH3CN (30 mL) of crude 6 (2.5 g) was cooled to 0° C., and treated with TMSBr (8 g, 52 mmol) for 5 hr. The reaction mixture was stirred with methanol for 1.5 hr at room temperature, concentrated, recharged with methanol, concentrated to dryness to give crude 7 which was used for next reaction without further purification.

المصدر