تفاعل #2076732

ord-f8eefa5d357541509fea83922ccd2dfe

معادلة التفاعل

N=C(NO)c1cccc(S(N)(=O)=O)c1
N-hydroxy-3-sulfamoyl-benzamidine
O=C(O)c1cc(C(F)(F)F)cc(-c2ccc(C(F)(F)F)cc2)n1
4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyridine-2-carboxylic acid
→
NS(=O)(=O)c1cccc(-c2noc(-c3cc(C(F)(F)F)cc(-c4ccc(C(F)(F)F)cc4)n3)n2)c1
title compound
NS(=O)(=O)c1cccc(-c2noc(-c3cc(C(F)(F)F)cc(-c4ccc(C(F)(F)F)cc4)n3)n2)c1
3-{5-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-[1,2,4]oxadiazol-3-yl}-benzenesulfonamide

المتفاعلات

N=C(NO)c1cccc(S(N)(=O)=O)c1
N-hydroxy-3-sulfamoyl-benzamidine
O=C(O)c1cc(C(F)(F)F)cc(-c2ccc(C(F)(F)F)cc2)n1
4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyridine-2-carboxylic acid

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

The title compound was prepared from N-hydroxy-3-sulfamoyl-benzamidine [CAS-No. 9000-88-7] (0.230 g, 1.06 mmol) and 4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyridine-2-carboxylic acid (example D.12) (0.30 g, 1.00 mmol) according to the general procedure V. Obtained as a white solid (0.100 g, 22%). MS (ISP) 513.2 [(M+H)+]; mp 211° C.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US07642264B2uspto-grants-2010_01