تفاعل #2075728

معادلة التفاعل

4,6-Dichloro-2-(4-chloro-2-fluoro-3-methoxyphenyl)-5-methoxy-pyrimidine

water

ammonia

→

title compound

المردود 88.0%

6-Chloro-2-(4-chloro-2-fluoro-3-methoxyphenyl)-5-methoxypyrimidin-4-ylamine

المردود 88.0%

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted with ethyl acetate thrice
2. 2
   غسيلThe combined organic phases were washed once with brine
3. 3
   أخرىdried
4. 4
   أخرىevaporated

الإجراء التجريبي

4,6-Dichloro-2-(4-chloro-2-fluoro-3-methoxyphenyl)-5-methoxy-pyrimidine (500 mg, 1.5 mmol) was suspended in ammonia saturated ethanol (10 mL) and heated in a CEM microwave at 125° C. for 30 min. The mixture was poured into 15 mL water and extracted with ethyl acetate thrice. The combined organic phases were washed once with brine, dried and evaporated to give the title compound (420 mg, 88% yield: 1H NMR (DMSO-d6) δ 7.59 (dd, 1H), 7.45 (br s, 2H), 7.39 (dd, 1H), 3.91 (s, 3H), 3.76 (s, 3H).

المصدر