تفاعل #2075717

معادلة التفاعل

Sodium borohydride

1-(5-bromo-2-chlorophenyl)ethanone

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title compound

المردود 99.3%

1-(5-Bromo-2-chlorophenyl)-ethanol

المردود 99.3%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىThe resulting bubbling white mixture
2. 2
   أخرىThe reaction mixture was quenched with acetone (50 mL)
3. 3
   تركيزconcentrated by rotary evaporation
4. 4
   أخرىThe residue was partitioned between ethyl acetate and water
5. 5
   أخرىThe organic phase was dried
6. 6
   تركيزconcentrated

الإجراء التجريبي

Sodium borohydride (1.182 g, 51.4 mmol) was added to a stirred solution of 1-(5-bromo-2-chlorophenyl)ethanone (10 g, 42.8 mmol) in methanol at 0° C., The resulting bubbling white mixture was allowed to warm to room temperature and stirred for 2 h. The reaction mixture was quenched with acetone (50 mL) and concentrated by rotary evaporation. The residue was partitioned between ethyl acetate and water. The organic phase was dried and concentrated to yield the title compound (10 g, 42.5 mmol, 99% yield) as a white solid: 1H NMR (CDCl3): δ 7.75 (d, 1H), 7.32 (m, 1H), 7.19 (m, 1H), 5.23 (q, 1H), 1.95 (d, 1H), 1.48 (d, 3H).

المصدر