تفاعل #2069929

معادلة التفاعل

4-cyano-4′-hydroxybiphenyl

allyl bromide

potassium carbonate

2-butanone

→

4-allyloxy-4′-cyanobiphenyl

المردود 91.3%

المذيبات

Water

ظروف التفاعل

المعالجة

1. 1
   أخرىA solution prepared
2. 2
   درجة الحرارةwas refluxed for 7 hours
3. 3
   غسيلthe organic layer was washed with water
4. 4
   تجفيفdried with anhydrous magnesium sulfate
5. 5
   أخرىThe solvent was evaporated away
6. 6
   أخرىthe resulting residue was purified through silica gel column chromatography
7. 7
   أخرىfurther recrystallized from ethanol

الإجراء التجريبي

A solution prepared by adding 20 g of 4-cyano-4′-hydroxybiphenyl, 20 g of allyl bromide and 25 g of potassium carbonate to 250 ml of 2-butanone was refluxed for 7 hours. Water was added to the reaction solution for liquid-liquid separation, and the organic layer was washed with water and dried with anhydrous magnesium sulfate. The solvent was evaporated away, and the resulting residue was purified through silica gel column chromatography using toluene as an eluent solvent and then further recrystallized from ethanol to obtain 22 g of 4-allyloxy-4′-cyanobiphenyl.

المصدر