تفاعل #2069926

معادلة التفاعل

N-Acetyl-N,N-di(4-isopropylphenyl)amine

→

N,N-Di-(4-isopropylphenyl)amine

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONThe ethanolic solution is poured into dist
2. 2
   ترشيحwater, and the brownish precipitate is filtered off with suction
3. 3
   workup.DISSOLUTIONdissolved in dichloromethane
4. 4
   تجفيفdried with sodium sulphate
5. 5
   تركيزThe solution is concentrated
6. 6
   أخرىchromatographed through a short silica gel column with 50% dichloromethane in hexane
7. 7
   تركيزThe product fractions are concentrated to dryness
8. 8
   أخرىthe product is dried under reduced pressure

الإجراء التجريبي

N-Acetyl-N,N-di(4-isopropylphenyl)amine (5.4 g, 18.4 mmol) are heated to reflux in 100 ml of 20% aqueous ethanol. The reaction is monitored by thin-layer chromatography. After 30 h, no reactant is any longer detectable in the TLC. The ethanolic solution is poured into dist. water, and the brownish precipitate is filtered off with suction, dissolved in dichloromethane and dried with sodium sulphate. The solution is concentrated and chromatographed through a short silica gel column with 50% dichloromethane in hexane. The product fractions are concentrated to dryness and the product is dried under reduced pressure.

المصدر