تفاعل #2067485

معادلة التفاعل

2-cyanoacetamide

2-(4-chlorophenyl)-3-(dimethylamino)acrolein

→

5-(4-CHLOROPHENYL)-3-CYANO-2-(1H)-PYRIDONE

المذيبات

Sodium

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added
2. 2
   درجة الحرارةThe mixture was refluxed for 1 hour
3. 3
   ترشيحthe resulting precipitate was filtered
4. 4
   غسيلwashed with ethanol
5. 5
   workup.DISSOLUTIONdissolved in hot water
6. 6
   ترشيحThe resulting precipitate was filtered
7. 7
   غسيلwashed with water

الإجراء التجريبي

Sodium (7 grams in 300 ml methanol) was stirred while a methanolic solution of 2-cyanoacetamide (16 grams) and 2-(4-chlorophenyl)-3-(dimethylamino)acrolein (37 grams) was added. The mixture was refluxed for 1 hour and the resulting precipitate was filtered, washed with ethanol, dissolved in hot water, and then acidified. The resulting precipitate was filtered, washed with water, and identified as the desired product, m.p. 278°-280° C.

المصدر