تفاعل #2057254

معادلة التفاعل

phenylguanidine carbonate

8-(3-dimethylamino-acryloyl)-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline 1-ethyl carboxylate

→

4-oxo-8-(2-phenylamino-pyrimidin-4-yl)-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline 1-ethyl carboxylate

المردود 44.1%

المذيبات

dimethylacetamide

ظروف التفاعل

المعالجة

1. 1
   أخرىthe solvent is evaporated
2. 2
   أخرىThe residue is triturated with acetonitrile
3. 3
   أخرىto give a solid which
4. 4
   ترشيحis collected by filtration
5. 5
   غسيلthen washed with acetonitrile
6. 6
   أخرىAfter drying

الإجراء التجريبي

51 mg (0.38 mmol) of phenylguanidine carbonate is added to a suspension of 88 mg (0.25 mmol) of 8-(3-dimethylamino-acryloyl)-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate in 2 mL of anhydrous dimethylacetamide. The mixture is stirred at 130° C. for 2 days then the solvent is evaporated. The residue is triturated with acetonitrile to give a solid which is collected by filtration then washed with acetonitrile then diisopropyl ether. After drying, 47 mg (44%) of 4-oxo-8-(2-phenylamino-pyrimidin-4-yl)-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate is obtained in the form of a brown solid.

المصدر