تفاعل #2045125

معادلة التفاعل

compound 2-1

1-(2,4-Dichloro-phenyl)-5-[4-(3-hydroxy-prop-1-ynyl)-phenyl]-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide

DCM

→

4-1

المردود 76.0%

1-(2,4-Dichloro-phenyl)-5-[4-(3-hydroxy-propyl)-phenyl]-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide

المردود 76.0%

المذيبات

THF

THF

ظروف التفاعل

المعالجة

1. 1
   ترشيحthe catalyst was filtered
2. 2
   تركيزthe residue was concentrated
3. 3
   أخرىpurified by flash column chromatography (petroleum ether-ethyl acetate, 6:4)

الإجراء التجريبي

To a magnetically stirred suspension of 14 mg of palladium (10 wt % on carbon) taken in 8 ml of THF was added compound 2-1 (80 mg, 0.165 mmol) dissolved in 3 ml of THF. The resulting mixture was stirred at room temperature for 2 h under an atmosphere of hydrogen. Then to the mixture was added 10 ml of DCM and the catalyst was filtered and the residue was concentrated and purified by flash column chromatography (petroleum ether-ethyl acetate, 6:4) to afford 61 mg (76%) of 4-1 as a white solid.

المصدر