تفاعل #2045123

معادلة التفاعل

dimethyl aminomalonate hydrochloride

dichloromethane

4-bromobenzoyl chloride

→

Dimethyl-2-(4-bromobenzoylamino)malonate

المذيبات

Water

ظروف التفاعل

المعالجة

1. 1
   أخرىthe organic layer will be separated
2. 2
   تجفيفdried over anhydrous MgSO4
3. 3
   أخرىThe evaporation of solvent
4. 4
   أخرىwill result in Int P

الإجراء التجريبي

To a stirred solution of dimethyl aminomalonate hydrochloride (1.83 g, 10 mmol) in dichloromethane (30 mL) triethylamine (3 mL, 22 mmol) will be added at 0° C. 4-bromobenzoyl chloride (2.19 g, 10 mmol) will be slowly added the resulting solution will be allowed to stand at room temperature overnight. Water will be added and the organic layer will be separated and dried over anhydrous MgSO4. The evaporation of solvent will result in Int P.

المصدر