تفاعل #2045114

معادلة التفاعل

1-methyl-4[({[4-(trifluoromethoxy)phenyl]amino}carbonyl)amino]-1H-pyrrole-2-carboxylic acid

1-Methyl-4-[({[4-(trifluoromethoxy)phenyl)amino}carbonyl)amino]-1H-pyrrole-2-carboxylic acid

O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate

1-(2-pyridyl)piperazine

→

N-{1-Methyl-5-[(4-pyridin-2-ylpiperazin-1-yl)carbonyl]-1H-pyrrol-3-yl}-N′-[4-(trifluoromethoxy)-phenyl]urea

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction solution is purified by RP-HPLC (acetonitrile/water)
2. 2
   أخرىThis gives a solid

الإجراء التجريبي

50 mg (0.15 mmol) of 1-methyl-4[({[4-(trifluoromethoxy)phenyl]amino}carbonyl)amino]-1H-pyrrole-2-carboxylic acid (Example 5A) are initially charged in 1 ml of DMF, and 56 mg (0.18 mmol) of O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate (TBTU) and 8.9 mg (0.07 mmol) of 4-(dimethylamino)pyridine (DMAP) are added. 29 mg (0.18 mmol) of 1-(2-pyridyl)piperazine are then added, and the mixture is stirred at RT for 8 h. The reaction solution is purified by RP-HPLC (acetonitrile/water). This gives a solid.

المصدر