تفاعل #2045113

معادلة التفاعل

1-(tert-butyloxycarbonyl)-4-(5-methylpyridin-2-yl)piperazine

hydrogen chloride

→

1-(5-Methylpyridin-2-yl)piperazine

المذيبات

dioxane

dioxane

ظروف التفاعل

المعالجة

1. 1
   تركيزThe mixture is then concentrated
2. 2
   استخلاصextracted repeatedly with dichloromethane
3. 3
   تجفيفThe combined organic phases are dried over sodium sulphate
4. 4
   تركيزconcentrated
5. 5
   أخرىdried under reduced pressure

الإجراء التجريبي

3.47 g (12.5 mmol) of 1-(tert-butyloxycarbonyl)-4-(5-methylpyridin-2-yl)piperazine are dissolved in 10 ml of dioxane, and 31 ml (125 mmol) of hydrogen chloride in dioxane (4 molar) are added. The mixture is stirred at RT for 2 h. The mixture is then concentrated and the residue is made alkaline using 1M aqueous sodium hydroxide solution and extracted repeatedly with dichloromethane. The combined organic phases are dried over sodium sulphate, concentrated and dried under reduced pressure.

المصدر