تفاعل #2045107

معادلة التفاعل

trichloroacetyl chloride

DCM

N-methylimidazole

DCM

→

product

1-Methyl-2-trichloroacetyl-1H-pyrrole

ظروف التفاعل

المعالجة

1. 1
   تركيزconcentrated
2. 2
   أخرىthe residue is purified over a flash frit (cyclohexane, cyclohexane/ethyl acetate 40:1)

الإجراء التجريبي

Under argon, 1.09 ml (12.3 mmol) of trichloroacetyl chloride are initially charged in 5 ml of DCM, and a solution of N-methylimidazole and 3 ml of DCM is added dropwise at RT over a period of 30 min. The reaction solution is allowed to stir at RT overnight and then concentrated, and the residue is purified over a flash frit (cyclohexane, cyclohexane/ethyl acetate 40:1). This gives the product as a liquid.

المصدر