تفاعل #2045054

معادلة التفاعل

2-[4-(6-Benzyloxyhexanoylamino)phenoxy]propionic acid methyl ester

→

79

المردود 51.6%

2-[4-(6-Hydroxyhexanoylamino)phenoxy]propionic acid methyl ester

المردود 51.6%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىCatalyst was removed by filtration and methanol
2. 2
   workup.DISTILLATIONdistilled off
3. 3
   أخرىThe crude 79 was purified by column chromatography on silica gel

الإجراء التجريبي

2-[4-(6-Benzyloxyhexanoylamino)phenoxy]propionic acid methyl ester 78 (15 g, 37.59 mmol) was dissolved in methanol (150 ml) in a pressure vessel, palladium on carbon (50% wet, 5%, 15 g) added and the mixture stirred under a hydrogen atmosph. (4 Kg) for 16 hrs. Catalyst was removed by filtration and methanol distilled off. The crude 79 was purified by column chromatography on silica gel using chloroform as eluant to get pure 79 (6 g, 51.6%) as a white powder. M.p: 62-64.5° C.

المصدر