تفاعل #2045053

معادلة التفاعل

4-(6-Benzyloxyhexanoylamino)phenoxyacetic acid methyl ester

→

77

المردود 24.4%

4-(6-Hydroxyhexanoylamino)phenoxyacetic acid methyl ester

المردود 24.4%

المذيبات

methanol

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   أخرىCatalyst was removed by filtration
2. 2
   workup.DISTILLATIONthe solvents were distilled off under vacuum
3. 3
   أخرىCrude 77 was purified by column chromatography on silica gel

الإجراء التجريبي

4-(6-Benzyloxyhexanoylamino)phenoxyacetic acid methyl ester 76 (24 grams, 62.33 mmol) was dissolved in a mixture of methanol (200 ml) and dimethylformamide (50 ml) in a pressure vessel, palladium on carbon (5%, 15 g) was added and the mixture stirred under a hydrogen atm. (4 Kg) for 24 hrs. Catalyst was removed by filtration, and the solvents were distilled off under vacuum. Crude 77 was purified by column chromatography on silica gel using chloroform as eluant to get pure 77 (4.5 g, 24.4%) as a white powder. M.p: 87.5-90.4° C.

المصدر