تفاعل #2045033

معادلة التفاعل

(4-Aminophenoxy)acetic acid methyl ester

(4-Nitro-phenoxy)-acetic acid-2-hydroxy-ethyl ester

→

46

المردود 22.8%

(4-Amino-phenoxy)-acetic acid 2-hydroxy-ethyl ester

المردود 22.8%

المذيبات

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   أخرىThe catalyst was removed by filtration, ethyl acetate
2. 2
   workup.DISTILLATIONwas distilled off
3. 3
   workup.ADDITIONhexane was added
4. 4
   ترشيحThe solid product was filtered
5. 5
   أخرىdried

الإجراء التجريبي

(4-Aminophenoxy)acetic acid methyl ester 41 (1 g, 4.15 mmol) was dissolved in ethyl acetate in a pressure vessel, palladium on carbon (5%, 0.5 g) was added and the mixture was stirred under an atmosphere of hydrogen (0.5 Kg) for one hour. The catalyst was removed by filtration, ethyl acetate was distilled off and hexane was added. The solid product was filtered and dried to give pure 46 (0.2 g, 22.8%) as a brown powder. M.p: 104-106.3° C.

المصدر