تفاعل #2045025

معادلة التفاعل

6-(4-Isocyanato-phenoxy)-hexanoic acid methyl ester

ethylene glycol

→

37

المردود 84.0%

6-[4-(2-Hydroxy-ethoxycarbonylamino)-phenoxy]-hexanoic acid methyl ester

المردود 84.0%

المذيبات

Water

ظروف التفاعل

المعالجة

1. 1
   أخرىrose to 46° C
2. 2
   ترشيحcrude 37 was filtered
3. 3
   أخرىdried
4. 4
   أخرىrecrystallised from toluene

الإجراء التجريبي

6-(4-Isocyanato-phenoxy)-hexanoic acid methyl ester 36 (15 g, 57 mmol) was added to ethylene glycol (50 ml) at room temperature. The reaction was exothermic and the temperature rose to 46° C. The reaction mixture was allowed to cool to room temperature and later stirred at room temperature for 16 hours. Water (150 ml) was added and crude 37 was filtered, dried and recrystallised from toluene to get pure 37 (12 g, 84%) as a white powder. M.p: 69.5-71.5° C.

المصدر