تفاعل #2045020

معادلة التفاعل

4-Nitro phenol

K2CO3

methyl chloroacetate

→

31

المردود 72.5%

Methyl(4-Nitro phenoxy)acetate

المردود 72.5%

المذيبات

acetone

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةrefluxed for 12 hours
2. 2
   workup.DISTILLATIONAcetone was distilled off
3. 3
   workup.ADDITIONwater (1500 ml) added
4. 4
   ترشيحCrude 31 was filtered
5. 5
   أخرىdried
6. 6
   أخرىrecrystallised from a mixture of ethyl acetate:hexane (1:5)

الإجراء التجريبي

To a mixture of 4-Nitro phenol (100 g, 719 mmol) and anhydrous K2CO3 (400 g, 2.894 moles) in anhydrous acetone (950 ml) was added methyl chloroacetate (114 g, 1.050 moles) and refluxed for 12 hours. Acetone was distilled off and water (1500 ml) added. Crude 31 was filtered, dried and recrystallised from a mixture of ethyl acetate:hexane (1:5) to give pure 31 (110 g, 72.5%) as a white fluffy powder. M.p: 97-98.4° C.

المصدر