تفاعل #2045018

معادلة التفاعل

(4-Isocyanato-phenoxy)-acetic acid methyl ester

ethylene glycol

→

29

المردود 82.9%

[4-(2-Hydroxy-ethoxycarbonylamino)-phenoxy]-acetic acid methyl ester

المردود 82.9%

المذيبات

Water

ظروف التفاعل

المعالجة

1. 1
   ترشيحcrude 29 was filtered
2. 2
   أخرىdried
3. 3
   أخرىpurified by column chromatography on silica gel

الإجراء التجريبي

(4-Isocyanato-phenoxy)-acetic acid methyl ester 28 (15 g, 72.46 mmol) was added to ethylene glycol (30 ml) at room temperature. The reaction was exothermic and the temperature raised to 42° C. Later the reaction mixture was stirred at room temperature for 16 hours. Water (100 ml) was added and crude 29 was filtered, dried and purified by column chromatography on silica gel using chloroform as eluant to get pure 29 (16.17 g, 82.9%) as a off-white powder. M.p: 85.5-87.5° C.

المصدر