تفاعل #2045015

معادلة التفاعل

4-aminophenol

sodium bicarbonate

benzyloxy acetyl chloride

→

26

المردود 48.9%

2-Benzyloxy-N-(4-hydroxy-phenyl)-acetamide

المردود 48.9%

المذيبات

acetone

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe solids were filtered off
2. 2
   workup.ADDITIONcold water (500 ml) was added
3. 3
   استخلاصCrude 26 was extracted into chloroform
4. 4
   غسيلwashed with 5% sodium bicarbonate solution (2×100 ml), water (2×100 ml)
5. 5
   تجفيفdried over sodium sulphate
6. 6
   workup.DISTILLATIONdistilled
7. 7
   أخرىThe crude 26 was purified by column chromatography on silica gel

الإجراء التجريبي

To mixture of 4-aminophenol (20 g, 183.2 mmol) and sodium bicarbonate (17 grams, 202 mmol) in acetone (150 ml) at 0° C. was added benzyloxy acetyl chloride (40 g, 216.8 mmol) drop wise, followed by stirring at room temperature for 20 hours. The solids were filtered off, and cold water (500 ml) was added. Crude 26 was extracted into chloroform, washed with 5% sodium bicarbonate solution (2×100 ml), water (2×100 ml), dried over sodium sulphate and distilled. The crude 26 was purified by column chromatography on silica gel using chloroform as eluant to get pure 26 (23 g, 48.9%) as a light orange syrup.

المصدر