تفاعل #2045010

معادلة التفاعل

6-(4-Acetylaminophenoxy)hexanoic acid methyl ester

6-(4-Acetylamino-phenoxy)-hexanoic acid methyl ester

hydrochloric acid

→

20

المردود 55.6%

6-(4-Amino-phenoxy)-hexanoic acid Hydrochloride

المردود 55.6%

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas refluxed for 48 hours
2. 2
   workup.DISTILLATIONExcess concentrated hydrochloric acid was distilled off in vacuum
3. 3
   ترشيحfiltered hot
4. 4
   ترشيحfiltered
5. 5
   أخرىdried

الإجراء التجريبي

A mixture of 6-(4-Acetylaminophenoxy)hexanoic acid methyl ester 19 (290 grams, 1.04 mol) in concentrated hydrochloric acid (7.12 L) was refluxed for 48 hours. Excess concentrated hydrochloric acid was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried give pure 20 (150 g, 55.6%) as a brown powder. The melting point was found to be 155-160° C.

المصدر