تفاعل #2045003

معادلة التفاعل

Paracetamol

K2CO3

ethyl bromoacetate

→

13

المردود 80.1%

(4-Acetylamino-phenoxy)-acetic acid ethyl ester

المردود 80.1%

المذيبات

acetone

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةrefluxed for 16 hours
2. 2
   workup.DISTILLATIONAcetone was distilled off
3. 3
   workup.ADDITIONwater (5 liter) was added
4. 4
   ترشيحCrude 13 was filtered
5. 5
   أخرىdried
6. 6
   أخرىrecrystallised from a mixture of toluene:hexane (1:5)

الإجراء التجريبي

To a mixture of Paracetamol (300 g, 1.984 mol), and anhydrous K2CO3 (1.80 Kg, 7.814 mmol) in anhydrous acetone (3 liters) was added ethyl bromoacetate (452 gr, 2.7 mol) and refluxed for 16 hours. Acetone was distilled off and water (5 liter) was added. Crude 13 was filtered, dried and recrystallised from a mixture of toluene:hexane (1:5) to give pure 13 (377 g, 80%) as a white shining powder. The melting point was found to be 104.2-106.2° C.

المصدر