تفاعل #2044994

معادلة التفاعل

methyl salicylate

K2CO3

methyl chloroacetate

→

1

المردود 17.0%

2-Methoxycarbonylmethoxy-benzoic acid methyl ester

المردود 17.0%

المذيبات

acetone

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةrefluxed for 36 hours
2. 2
   workup.DISTILLATIONThe acetone was distilled off
3. 3
   workup.ADDITIONwater (1200 ml) was added
4. 4
   استخلاصCrude 1 was extracted into chloroform
5. 5
   تجفيفdried over Na2SO4
6. 6
   workup.DISTILLATIONdistilled
7. 7
   أخرىpurified by column chromatography on silica gel

الإجراء التجريبي

To a mixture of methyl salicylate (100 g, 657 mmol) and anhydrous K2CO3 (360 g, 2.605 mol) in anhydrous acetone (1000 ml) was added methyl chloroacetate (94 g, 866 mmol) and refluxed for 36 hours. The acetone was distilled off and water (1200 ml) was added. Crude 1 was extracted into chloroform, dried over Na2SO4 distilled and purified by column chromatography on silica gel using hexane as eluant to give pure 1 (25 grams, 17%) as a light yellow syrup.

المصدر