تفاعل #2044323

معادلة التفاعل

1-benzyloxycarbonylamidino-4-mesyloxyethyl piperidine

sodium azide

water

→

4-Azidoethyl-1-benzyloxycarbonylamidino piperidine

المذيبات

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added
2. 2
   استخلاصextracted with ethyl acetate three times
3. 3
   غسيلThe combined organic phase was washed with water
4. 4
   تجفيفdried (Na2SO4)
5. 5
   أخرىevaporated
6. 6
   أخرىchromatographed on silica gel

الإجراء التجريبي

In 100 ml of dimethylformamide was dissolved 4.4 g (0.0115 mol) of crude 1-benzyloxycarbonylamidino-4-mesyloxyethyl piperidine and 4.5 g (0.069 mol) of sodium azide was added. The mixture was heated at 100° C. for 2.5 h. It was then poured into water and extracted with ethyl acetate three times. The combined organic phase was washed with water, dried (Na2SO4) and evaporated. The residue was flash chromatographed on silica gel using ethyl acetate/heptane 1/1 as eluent. Yield: 3.0 g (79%).

المصدر