تفاعل #2030970

معادلة التفاعل

8-chloro-7-(2-propen-1-yl)-3,7-dihydro-1H-purine-2,6-dione

sodium carbonate

4-bromo-1,1,1-trifluorobutane

→

8-chloro-7-(2-propen-1-yl)-3-(4,4,4-trifluorobutyl)-3,7-dihydro-1H-purine-2,6-dione

المردود 57.0%

المذيبات

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction mixture was partitioned between ethyl acetate and water
2. 2
   أخرىThe organic phase was separated
3. 3
   غسيلwashed with hydrochloric acid (2N), brine
4. 4
   تجفيفdried (MgSO4)
5. 5
   أخرىevaporated to dryness
6. 6
   أخرىThe crude product was triturated with ether
7. 7
   ترشيحthe solid collected by filtration

الإجراء التجريبي

8-chloro-7-(2-propen-1-yl)-3,7-dihydro-1H-purine-2,6-dione (1.5 g, 6.64 mmol), sodium carbonate (844 mg, 7.9 mmol) and 4-bromo-1,1,1-trifluorobutane (1.39 g, 7.3 mmol) were stirred in dimethylformamide (25 ml, dry) for seven days. The reaction mixture was partitioned between ethyl acetate and water. The organic phase was separated and washed with hydrochloric acid (2N), brine, dried (MgSO4) and then evaporated to dryness. The crude product was triturated with ether and the solid collected by filtration to afford 8-chloro-7-(2-propen-1-yl)-3-(4,4,4-trifluorobutyl)-3,7-dihydro-1H-purine-2,6-dione as a white solid (1.23 g, 57%). m/z 337 [MH+].

المصدر