تفاعل #2028955

معادلة التفاعل

13

(S)-8-amino-9,10-difluoro-3-methyl-6-(1H-tetrazole-5-yl)-2H-(1,4)oxazino(2,3,4-ij)quinolin-7(3H)-one

3-(1H-imidazol-1-yl)propan-1-amine

→

title compound

(S)-10-(3-(1H-imidazol-1-yl)propylamino)-8-amino-9-fluoro-3-methyl-6-(1H-tetrazol-5-yl)-2H-(1,4)oxazino(2,3,4-ij)quinolin-7(3H)-one

المذيبات

DMSO

DMSO

ظروف التفاعل

المعالجة

1. 1
   أخرىwas removed
2. 2
   أخرىthe remaining solid was purified by preparative HPLC
3. 3
   workup.ADDITIONTo the combined HPLC fractions containing the product
4. 4
   workup.ADDITIONwere added several drops of 1 N HCl before they
5. 5
   أخرىwere dried down

الإجراء التجريبي

To a solution of 13 (250 mg, 0.78 mmol) in 5 ml of DMSO were added 132 μl (1.17 mmol) of 3-(1H-imidazol-1-yl)propan-1-amine. The reaction mixture was heated to 120° C. for 1 h. Upon completion of the reaction the DMSO was removed and the remaining solid was purified by preparative HPLC. To the combined HPLC fractions containing the product were added several drops of 1 N HCl before they were dried down to generate the HCl salt of the compound. The title compound was obtained as a yellow solid (118 mg, 37% yield).

المصدر