تفاعل #2028954

معادلة التفاعل

nitrile

(S)-8-amino-9,10-difluoro-3-methyl-7-oxo-3,7-dihydro-2H-(1,4)oxazino(2,3,4-ij)quinoline-6-carbonitrile

sodium azide

→

13

المردود 60.2%

(S)-8-amino-9,10-difluoro-3-methyl-6-(1H-tetrazole-5-yl)-2H-(1,4)oxazino(2,3,4-ij)quinolin-7(3H)-one

المردود 60.2%

المذيبات

isopropanol

water

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe precipitates were collected by filtration
2. 2
   غسيلwashed with water
3. 3
   أخرىThe solid was dried under vacuum

الإجراء التجريبي

To a mixture of nitrile 5 (40 mg, 0.14 mmol) in isopropanol and water (1:1 v/v, 15 ml) were added 20 mg of sodium azide (0.29 mmole) and 22 mg of zinc chloride (0.29 mmole). The mixture was heated to 110° C. for 18 h. The precipitates were collected by filtration and washed with water. The solid was dried under vacuum to give 27 mg (60% yield) of 13. This title compound was used without further purification in the next step.

المصدر