تفاعل #2028953
ord-aed92f7c15fe444e8611d464f47606ef
معادلة التفاعل
12
8-amino-9,10-difluoro-3,3-dimethyl-7-oxo-3,7-dihydro-2H-(1,4)oxazino(2,3,4-ij)quinoline-6-carbonitrile
3-(pyridin-2-yl)propan-1-amine
→
title compound
المردود 29.1%
8-amino-9-fluoro-3,3-dimethyl-7-oxo-10-(3-(pyridin-2-yl)propylamino)-3,7-dihydro-2H-(1,4)oxazino(2,3,4-ij)quinoline-6-carbonitrile
المردود 29.1%
المتفاعلات
الكواشف
لا شيء
المذيبات
ظروف التفاعل
درجة الحرارة
120°CELSIUS
الظروف التفصيلية
See reaction.notes.procedure_details.
المعالجة
- 1درجة الحرارةAfter cooling
- 2أخرىdried
- 3أخرىto remove DMSO
- 4أخرىthe remaining solid was purified by preparative HPLC
الإجراء التجريبي
To a solution of 12 (250 mg, 0.86 mmol) in 4 ml of DMSO, 268 mg (1.98 mmol) of 3-(pyridin-2-yl)propan-1-amine were added. The reaction mixture was heated to 120° C. for 5 h. After cooling, the reaction mixture was freeze dried to remove DMSO and the remaining solid was purified by preparative HPLC to give the title compound as a yellow solid (102 mg, 29% yield).