تفاعل #2028951

معادلة التفاعل

10

9,10-difluoro-3,3-dimethyl-8-nitro-7-oxo-3,7-dihydro-2H-(1,4)oxazino(2,3,4-ij)quinoline-6-carboxamide

sodium hydrosulfite

→

11

المردود 51.0%

8-amino-9,10-difluoro-3,3-dimethyl-7-oxo-3,7-dihydro-2H-(1,4)oxazino(2,3,4-ij)quinoline-6-carboxamide

المردود 51.0%

المذيبات

water methanol

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added
2. 2
   درجة الحرارةthe suspension was refluxed for 5 h until all starting material
3. 3
   أخرىwas consumed
4. 4
   ترشيحThe product was collected by filtration while the mixture
5. 5
   غسيلwashed with warm water
6. 6
   أخرىThe solid was dried under vacuum

الإجراء التجريبي

To a suspension of 10 (6.3 g, 18.6 mmol) in a mixture of water/methanol 1/1 v/v (160 mL), sodium hydrosulfite (19.4 g, 116 mmol) was added and the suspension was refluxed for 5 h until all starting material was consumed. The product was collected by filtration while the mixture was still hot and washed with warm water. The solid was dried under vacuum to give 11 (2.92 g, 51% yield).

المصدر