تفاعل #2028950

معادلة التفاعل

8

9,10-Difluoro-3,3-dimethyl-7-oxo-3,7-dihydro-2H-(1,4)oxazino(2,3,4-ij)quinoline-6-carboxylic acid

KNO3

→

9

المردود 87.9%

9,10-difluoro-3,3-dimethyl-8-nitro-7-oxo-3,7-dihydro-2H-(1,4)oxazino(2,3,4-ij)quinoline-6-carboxylic acid

المردود 87.9%

المذيبات

H2SO4

ظروف التفاعل

المعالجة

1. 1
   أخرىthe resulting precipitate was removed by filtration
2. 2
   غسيلwashed with ice-cold water
3. 3
   أخرىThe resulting solid was dried

الإجراء التجريبي

A solution of 8 (7.5 g, 25.4 mmol) in concentrated H2SO4 (30 mL) was treated portionwise at 0° C. with solid KNO3 (3.9 g, 38.6 mmol). After stirring at 0° C. for 2 h, the reaction mixture was poured into 500 mL of ice-water and the resulting precipitate was removed by filtration and washed with ice-cold water. The resulting solid was dried to yield 9 as a yellow solid (7.6 g, 87% yield).

المصدر